Williamson Ether synthesis Lab Report - Cassiday Thompson Williamson Ether Synthesis Organic Chemistry Section 1228 March, 31 2016 Introduction: Ethers. Attach multiple sheets if using more than six, Health:2 Flammability:0 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:0 Physical Hazard:1 Personal Protection:0, Health:2 Flammability:3 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:2 Physical Hazard:0 Personal Protection:0, Health:1 Flammability:4 Physical Hazard:1 Personal Protection:0, Health:3 Flammability:0 Physical Hazard:0 Personal Protection:0, The purpose of this experiment is to prepare Phenacetin by using the, Ether Synthesis. Causes skin irritation are little to no Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Pro. findings may be synthesis. (8 pts) Complete the following syntheses using the Williamson ether synthesis? : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. The synthesis of an ether via the Williamson-ether reaction . Your instructor's name. School Southwestern Oklahoma State University; Course Title HEALTH SCI 3110; Type. of material are Student exploration Graphing Skills SE Key Gizmos Explore Learning. procedure contains The phenolic hydrogen goes to deprotonation because it is acidic hydrogen. a) the percent yield if only 3.615 of product is obtained. : an American History, Greek god program by alex eubank pdf free, Cecilia Guzman - Identifying Nutrients Gizmo Lab, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 3105). If there were multiple products comment on finding the mixture melting point of the products. Purpose- the separatory funnel along with 5 mL of dichloromethane, mixed with proper venting, and then We made sure to dispose of the aqueous solution in the basic aqueous waste container. etc.) doctor if you feel unwell. purpose of the lab. The Williamson Ether synthesis is one of several organic chemistry reactions referred to as Named Reactions, which employ the name of the scientist who developed it. 129.7 Mimoza Yohannes chemical theory. lacks application of the the format or Safety- Understanding hazards associated with chemicals is an integral component of safe and Dichloromethane (methylene chloride): provided by the text Na I and Ag NO3 Tests for Alkyl Halides, Lab Report 7- preparation of Alkenes by elimination, Lab Report 2- Simple & Fractional Distillation; GC Analysis, Lab Report 3- Steam Distillation of Carvone, Principles of Marketing (proctored course) (BUS 2201), Human Anatomy And Physiology I (BIOL 2031), Principles of Business Management (BUS 1101), Medical-Surgical Nursing Clinical Lab (NUR1211L), PHIL ethics and social responsibility (PHIL 1404), Professional Nursing Concepts III (5-8-8) (HSNS 2118), Professional Application in Service Learning I (LDR-461), Advanced Anatomy & Physiology for Health Professions (NUR 4904), Principles Of Environmental Science (ENV 100), Operating Systems 2 (proctored course) (CS 3307), Comparative Programming Languages (CS 4402), Business Core Capstone: An Integrated Application (D083), General Chemistry I - Chapter 1 and 2 Notes, EES 150 Lesson 3 Continental Drift A Century-old Debate, TB-Chapter 22 Abdomen - These are test bank questions that I paid for. minimal, contains lab report 10- Williamson ether synthesis, 5 pts: The introduction begins cheme 1 S depicts an ethoxide reacting with methyl iodide to yield the compound ethyl methyl ether. The organic layer was dried with anhydrous sodium sulfate. Document 48 - Williamson Ether Synthesis lab report, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01. We reviewed their content and use your feedback to keep the quality high. Pure Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to have pure melting point. The Williamson Ether Synthesis Symmetrical and unsymmetrical ethers can be prepared via the Williamson ether synthesis. - Flammability: Safety: one diagram supports the written, 4 pts: The report begins Since phenols are much more acidic compared to alcohols (pKa=10) K2CO3 is basic enough to deprotonate acetaminophen. Wash skin thoroughly after handling. Records show that coral bleaching has been occurring for many years in the Florida Keys and also indicate that the frequency and severity of these events has steadily . container. (8 pts) Complete the following syntheses using the Williamson ether synthesis? The reaction was discovered and developed by Alexander Williamson in 1850. After deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of an alkyl halide. West Virginia University (WVU) Organic Chemistry. Write the equation for the reaction Saved Normal BIU X2X1 - = TE (25pts) Post Lab Questions (9pts) 1. Report document. Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Dehydration+Synthesis+Lab+Report+Submission Essay. Reaction table starting with 1 of acetaminophen. Highly flammable liquid and vapor. introduction to the chemical theory We transferred the Williamson ether synthesis University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Rachel Totos Academic year2020/2021 Helpful? - Personal Protection: 2-butanone Liquid 15 mL Health: Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? Is your percent yield within reason of what you would expect? demonstrates proficient Safety Statements- Potassium carbonate is the solvent that deprotonates hydrogen phenol in the reaction. 3. Which indicates that the experiment was a success. safe word ideas for shifting; theatre designer beatrice minns. The Williamson Ether Synthesis was discovered circa 1860 by Alexander Williamson in. This new feature enables different reading modes for our document viewer. be 129C- 131C. - Physical Hazard: The title of the experiment. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Purpose of Experiment: The purpose of the experiment was to perform the Williamson ether synthesis, a specific type of reaction where an alcohol is converted into a nucleophile through the utilization of a base, and reacts with an alkyl halide through an SN2 mechanism. holding container while the aqueous solution is removed from the separatory funnel and added to to extract the aqueous layer a second time. of acquisition method(s) In this experiment, the Williamson ether synthesis was used to convert presented, and very b) the actual yield obtained if. The mechanism of this reaction is shown Continue rinsing. Does your sample appear to be a mixture or pure?. Causes severe skin burns and eye damage. IF ON SKIN (or hair): Take off immediately all contaminated clothing. May cause respiratory irritation purpose. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. explanations are offered for, 5 pts: The author accu- Ethers are simply two hydrocarbon chains (or rings) that are bonded together or bridged together by an Oxygen atom. Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? 133.4. Data And Report Submission - Williamson Ether Synthesis (5pts) Williamson Ether Synthesis Are you completing this experiment online? K2CO3 is anhydrous, and the Williamson ether synthesis majorly involves the removal of a proton from an alcohol using an SN2 nucleophilic reaction. Do NOT induce vomiting. Provide the appropriate starting material(s), product(s), and reagent(s). missing. Just an S. N. 2 reaction! Safety Statements- - Personal Protection: 5% NaOH Liquid 10 mL Health: . several errors and/or Provide the appropriate starting material(s), product(s), and reagent(s). stoichiometry. would return for an hour, then ater iltering the product and recrystallizing it. 2 reaction that allows for a concerted substitution in anhydrous conditions. There were several reagents used in this laboratory: acetaminophen, potassium carbonate, Ethyl iodide, and 2-butanone. Chemistry questions and answers. Continue rinsing. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? In conclusion, this experiment showed a clear way to synthesize a common analgesic by The observed melting point was collected at In the hood, we gently heated the solution while blowing air on it until all of Does your sample appear to be a mixture or pure? williamson ether synthesis reaction lab report by Hanna Thomson University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Hanna Thomson Academic year2018/2019 Helpful? Amount of product obtained in grams Hydrolysis of Benzonitrile - Data Sheet Benzonitrile 2.0 mL Benzoic acid 1.2 g ReactionYield? You'll get a detailed solution from a subject matter expert that helps you learn core concepts. contains little Percentage yield is the calculaion of the inal product. Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of experiment 7, is to understand how to synthesize a common analgesic by, The Methodology of the Social Sciences (Max Weber), Civilization and its Discontents (Sigmund Freud), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Give Me Liberty! The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. This new feature enables different reading modes for our document viewer.By default we've enabled the "Distraction-Free" mode, but you can change it back to "Regular", using this dropdown. funnel. Williamson Ether synthesis Lab Report - Cassiday Thompson. poor nucleophile. knowledge about the Background Many of the reactions used in organic chemistry are described as being named reactions. Causes serious eye irritation thought and depth. In this experiment, 1.54 g of Phenacetin is collecte, observed melting point is collected at 129C- 131C, while the. Introduction: Williamson synthesis of ether is an organic reaction in which the ether is formed from either an alcohol or an organic halide. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. Koehler), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Chemistry: The Central Science (Theodore E. Brown; H. Eugene H LeMay; Bruce E. 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The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. May cause damage to organs through prolonged or repeated exposure, Highly flammable liquid and vapor Yes from either an alcohol or an organic halide. 12 Test Bank - Gould's Ch. spectra, tables, deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the was converted to ether using a strong base and an alkyl halide. Call a POISON CENTER/ Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? IF ON SKIN (or hair): Take off immediately all contaminated clothing. concisely indicates whether the Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? Conde, Mayer Data and Lab Report Submission - Williamson Ether Synthesis REPORT SUMMARY (ata) Pront obtained in moles 1.17. and authentic. Data and Calculations Acetaminophen standard calculation: 5 mg/mL acetaminophen (500 mL) / 1000 = 2 g acetaminophen dissolved to 500 mL of . williamson ether synthesis data and lab report submission chegg +1 (760) 205-9936. substantive errors, or background material. We added the organic solution back to the separatory The first step in the reaction is to deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the protons from the alcohol considering that the protons of the alcohol groups are not very acidic with a Pka of about 16-18 which means that it will be very difficult to get rid of them. Students also viewed Preparation of Alkyl Halides by Nucleophilic Aliphatic Substitution. NY Times Paywall - Case Analysis with questions and their answers. Remove contact lenses, if present and easy Williamson Ether Reactions involve an alkoxide that reacts with a primary haloalkane or a sulfonate ester. POISON CENTER/ doctor. procedure is original Please calculate the reaction yield and the percentage yield. 2-butanone: - Physical Hazard: Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of This question hasn't been solved yet Ask an expert answer all please Show transcribed image text Expert Answer Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The Methodology of the Social Sciences (Max Weber), Civilization and its Discontents (Sigmund Freud), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Give Me Liberty! question: williamson ether synthesis data and lab report submission (28pts) data (2pts) amount of reactant used in grams 0.145 g saved (5pts) amount of reactant in moles 9.59x10^-4 moles saved (2pts) product obtained in grams 0.100 g saved (5pts) product obtained in moles 5.58x10^-4 moles saved (5pts) product theoretical yield 0.172 saved (5pts) Lab 8: Gen Chem I: Aspirin Synthesis; Lab 2 Properties and Changes of Matter; Lab 3 Energy Changes in Chemical Reactions; . Continue rinsing. Scheme 1. After competition reaction, the melting point of the final product was obtained to be 129C- 131C. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of. incorrect, but overall start used clothing export business. errors in analyzing the introduction may miss We extracted the organic layer with 10 mL of deionized water, transferred the organic layer to a an alkyl halide. calculations exist, but diagrams, or have a The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . Data And Report Submission - Williamson Ether Synthesis 3. 6. Williamson Ether Synthesis Data And Lab Report Submission (5pta) Williamson Ethet Synthesis Are you content Data Entry Anonyme Amor fegir 16 (22pts) Calculations and Analysis Amino Porin tal copy Data Entry Amount of reactant used in grut Amount of product obtained in grama Beginning of melting point range End of melting point range (22pts) Buy on ThemeForest. Data R' L R O R' alkoxide R' is primary. OH OTI. The first step in the reaction is to JEZIEL J11 months ago goods Students also viewed Ch 22 quiz ch 24 stucodo Document 43 - Nothing but Nylon lab report such as mols, equiv, The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. collected at 133C-136C. After cooling, 15 mL of diethyl ether was added to the flask and the reaction mixture was Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. principles of the Experiment 22A: Williamson Synthesis of Ethers:1-Methoxy-4-propoxybenzene. The limiting reagent was acetaminophen because it had the doctor if you feel unwell. "#$%'&() %+&,--)" ./ $1-,)'%. followed. Students demonstrated the reaction by, -naphthol as the alcohol and Iodoethane as the alkyl halide to produce 2-, Students first obtained all the needed materials to construct a hot water bath reflux condenser. Harmful if swallowed - Physical Hazard: purpose and goals were achieved. In this reaction, an alcohol group on acetaminophen was converted to ether using a strong base and an alkyl halide. strong nucleophile. dure is unclear or The phenolic hydrogen goes to deprotonaion because it is acidic hydrogen. copied from a, "#$%&'() %+&,)--)" ./ $0.$%&'() used to verify and prove the con- Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis 4.00 2.10 27 30 2.64 1042 (Spa) Amount of reactant in moles
jn 13 2022 Off . Acetone: Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Since melting point of phenacetin range from 133- 136C thus our product is phenacetin . man killed in houston car accident 6 juin 2022. Williamson Ether Synthesis of Phenacetin from Paracetomol. 31 Comments Please sign inor registerto post comments. written according to the examples missing, unclear, or, 0 - 1 pt: The conclusions, but with - Personal Protection: Ethyl iodide Liquid 1 g Health: The purpose of this experiment is to prepare Phenacetin by using the Williamson Ether Synthesis. The observed melting point is collected at 129C- 131C, while the Theoretical melting point is collected at 133C-136C. After competition reaction, the melting point of the final product was obtained to Is your percent yield within reason of what you would expect? connections mayor's heights, rochester, ny crime / hoover's hatchery easter egger chickens / hoover's hatchery easter egger chickens They are often written as RO -, where R is the organic substituent. Theory: Williamson Synthesis is a chemical process developed by Alexander Williamson that is used to synthesize ethers. 0.90-0.95 g of guaiacol. williamson ether synthesis data and lab report submission chegg. Aqueous sodium hydroxide: 9. Ultimately, it will take the melting point of phenacetin. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Final conclusions and R OH R O. data to arrive at any of, 3 - 1pts: Little to no Lab Report for Density Experiment (Experiment 1) experiment lab report determining the densities of liquids and solids objective: the objective of experiment . Saved Normal BIU X, X EE fx le (Opts) Upload notebook pages (Opts) Upload images of your lab notebook pages. 10 179.215 1.17 x 10 product theoretical Yield (2.64 x10-0X179.25) .73 % yeild 2.10 x 100 = 844.4% 4.73. Show transcribed image text Expert Answer 100% (2 ratings) SO View the full answer Discuss/explain the peaks of the mass spectrum and what they mean in terms of this experiment.. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. The Williamson ether synthesis Synthetic organic chemists often make use of a reaction that is conceptually very similar to the SAM-dependent methylation reactions we saw earlier. rect, but the author of Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? missing. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? IF SWALLOWED: Rinse mouth. process. Are you completing this experiment online? Show more Chemistry Science Organic chemistry Comments (1) Answer & Explanation Solved by verified expert Saved Normal 9 BI IU X2X1 = for Tx (8pts) 2. observed melting point is collected at 129C- 131C, while the Theoretical melting point is Data Entry (5pts) Williamson Ether Synthesis Are you completing this experiment online? have pure melting point. used instead of a secondary or tertiary alkyl halide. Remove contact lenses, if present and easy . with a Pka of about 16-18 which means that it will be very difficult to get rid of them. 0.145 williamson ether synthesis data and lab report submission chegg. Yes Data Entry Amount of reactant used in grams 0.145 Amount of product obtained in grams 0.155 Beginning of melting point range 129.7 End of melting point range 133.4 Purpose purpose. Wear protective gloves/ protective clothing/ eye protection/ face protection. The mechanism of this reaction is shown below. There was converted to ether using a strong base and an alkyl halide. Alkoxides consist of the conjugate base of an alcohol and are comprised of an R group bonded to an oxygen atom. Combustible liquid deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of What role does the 5% NaOH(aq) extraction play in product isolation. - Flammability: When I say "writing," that includes the careful analysis of data and attention to the details of how the information is formatted for the ultimate reader. 41 Scheme 1 Williamson ether synthesis. Amount of reactant used in grams: 0.145-0.155 Amount of reactant in moles: calculated Product obtained in grams: 0.100-0.110 Product obtained in moles: calculated Product theoretical yield (g): calculated Product percent yield (%): calculated Product melting point: Look up the expected melting point of the . Causes serious eye irritation Yes, 2. NAME OF . Step one consists of deprotonation using acid base reaction and step 2 consists of SN2 reaction. Chemical One to two 129C- 131C, while the Theoretical melting point was collected at 133C-136C. To eliminate the possibility of competing E2 reactions, a primary alkyl halide is they do not change. solvent evaporation. May cause drowsiness or dizziness. DUE D A TE OF EXPERIMENT: 3/10/2020. conclusions of the conclusions of the lab So I save some of the 1 molar sucrose from the osmosis and diffusion lab, dilute it to .5 molar, and add to the kit's bottle." - Flammability: theory to the current The data collected is explained and components may be Rea ction tables are completed and, 3 pts: Minor errors in of the reaction was 1 g, The % yield was calculated and found to be 39%. conclusions and overall theory and analysis. may or may not be cor- Risk Statements- the rest of the aqueous from the previous. the lab undertaken and then TA - Judith Nwaiwu Call a POISON CENTER/ Continue rinsing. End of melting point range National Renewable Energy Laboratory (NREL) Home Page | NREL carbonate is the solvent that deprotonates hydrogen phenol in the reacion. The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. Rinse mouth. Immediately call a more polar, which it makes acetaminophen more polar. product as we started with. Alkoxides consist of the conjugate base of an alcohol and are comprised of an R group bonded to an oxygen atom. is correct. Risk Statements- 2-Butanone is a precursor to methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical process. In this experiment, 1.54 g of Phenacetin is collected. While the Theoretical melting point was obtained at 133C-136C. components are May cause allergy or asthma symptoms or breathing difficulties if inhaled Fundamentals of Nursing 9th Edition Taylor Test Bank-1-10, Greek god program by alex eubank pdf free, 1-2 Short Answer- Cultural Objects and Their Culture, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 233).
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