Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Applies only to oral form of both agents. Corrected Sodium and Effective Osmolality. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Contraindicated. Applies only to oral form of both agents. Do not double the dose to catch up. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Dose. 2012;2(4):288-335. Use Caution/Monitor. 2. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Applies only to oral form of both agents. Applies only to oral form of both agents. elemental iron (mg/ml) in the product being used: Where C= Nutr Clin Pract. Information last revised December 2022. No additional iron to replenish stores. Most Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Schweiz Med Wochenschr; 100(7):301-3. Venofer treatment may be repeated if necessary. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. Before using, check this product visually for particles or discoloration. Avoid or Use Alternate Drug. Applies only to oral form of both agents. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Max Dose. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Minor/Significance Unknown. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Venofer may reduce the absorption of concomitantly administered oral iron preparations. 1. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Minor/Significance Unknown. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. This drug is available at the lowest co-pay. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Applies only to oral form of both agents. Administer Venofer only intravenously by slow injection or by infusion. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Applies only to oral form of both agents. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Controlled studies in pregnant women show no evidence of fetal risk. Applies only to oral form of both agents. Discuss the risks and benefits with your doctor.This medication passes into breast milk. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Avoid or Use Alternate Drug. Reference www.medicines.org.uk Background Applies only to oral form of both agents. Use Caution/Monitor. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. (3) Known hypersensitivity to Venofer. 2000 Jan;22(1):39-43. Step 2: Calculation and administration of the maximum individual iron dose(s): . Applies only to oral form of both agents. . This document does not contain all possible drug interactions. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Due Date form Ultrasound Report. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Avoid or Use Alternate Drug. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Oral and parenteral products - see background option for oral products. Kidney Int. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Dosing: (a) Divide calculated total cumulate dose . Jacobs P, Dommisse J. Applies only to oral form of both agents. official version of the modified score here. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Kumpf VJ, Holland EG. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Avoid or Use Alternate Drug. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Use Caution/Monitor. Venofer treatment may be repeated if necessary. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Ren Fail. Interaction only with oral iron administration. informational and educational purposes only. Feraheme does not contain antimicrobial preservatives. Slowing the infusion rate may alleviate symptoms. Use Caution/Monitor. Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. Applies only to oral form of both agents. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Applies only to oral form of both agents. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Avoid or Use Alternate Drug. 4. Use Caution/Monitor. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Consult your pharmacist or local waste disposal company. Applies only to oral form of both agents. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Iron sucrose: 20 mg/mL. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. By clicking send, you acknowledge that you have permission to email the recipient with this information. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. . Use Caution/Monitor. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Administer while the patient is in a reclined or semi-reclined position. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Baloxavir may bind to polyvalent cations resulting in decreased absorption. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Avoid or Use Alternate Drug. If either is present, do not use the liquid. Use Caution/Monitor. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor/Significance Unknown. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. 2010;18(3). Avoid or Use Alternate Drug. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. The dosage of Venofer is expressed in mg of elemental iron. Crown Rump Length and Nuchal Translucency. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Iron deficiency anemia is the type of anemia caused by iron depletion. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. A healthcare provider will give you this injection. DICP. Administer on 5 different occasions over a 14 day period. Use Caution/Monitor. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Use Caution/Monitor. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Reactions have occurred following the first dose or subsequent doses of Venofer. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. World J Gastroenterol; 16(22): 27202725. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Written by ASHP. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Use Caution/Monitor. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Available for Android and iOS devices. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Interaction only with oral iron administration. Applies only to oral form of both agents. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Anemias. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Applies only to oral form of both agents. Generic name: IRON SUCROSE 20mg in 1mL When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Your doctor will do laboratory tests to monitor your response. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Modify Therapy/Monitor Closely. This drug is available at a higher level co-pay. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. 2010;18(3). Applies only to oral form of both agents. 1 ,*. Applies only to oral form of both agents. Use Caution/Monitor. 1) Ganzoni AM. Calculates iron deficit for dosing iron. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Applies only to oral form of both agents. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Deferasirox chelates iron. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. J Lab Clin Med. ONE DOSE. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Accessed: 4/12/2011. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Applies only to oral form of both agents. Fulminant symptoms include confusion, sensation of passing out, paleness. restrictions. Applies only to oral form of both agents. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. an automated flowchart approach. Minor/Significance Unknown. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals.