Is an uncertain result possible, and what would that mean? Prothrombin G20210A (Factor II Mutation) Resources. Prevention and Treatment of Excessive Blood Clotting (Hypercoagulation). professional diagnosis, opinion, treatment, or services to you or any individual. Most people with factor V Leiden never develop abnormal clots. About 1 in every 50 white people in Europe and North America has the heterozygous prothrombin gene mutation, making it the second most common inherited clotting disorder. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. Make a donation. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. If you believe Start With This 7-Day Meal Plan, 10 Effortless Ways to Finally Cut Down on Salt. Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. If you are overweight or obese, consider the benefits of losing weight. You do need treatment with blood thinners if you have had a blood clot or develop one in the future. Talk with your health care provider about how to do this safely. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. There are 2 copies for Factor V gene, which are passed down from our parents. What's more, they can help lower blood pressure. while also discussing the various products Sartorius produces in order to aid in this. pph~~&"V: 9EP. Barbara Woodward Lips Patient Education Center. Want to talk about Multiple Myeloma: Anyone else? This site complies with the HONcode standard for trustworthy health information: verify here. Becoming a Vegetarian: Foods to Choose From. It has been suggested as a risk factor for RPL as it triggers thrombophilia and impairs the initial vascularization process at implantation [ 6 ]. If you have kidney disease, there may be too much protein in this diet for you. This helps your mood and gives you energy all day long. Advertising revenue supports our not-for-profit mission. If youre taking anticoagulants (blood thinners), be aware that you may bleed or bruise more easily, which is why it is very important to have regular follow-up medical appointments with your provider. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. If you have factor V Leiden, you may have many questions. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Venous thromboembolism. 0000022790 00000 n Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Pruthi RK (expert opinion). Bauer KA. In general, its more common among people who are white in the U.S. and Europe. 2005 - 2023 WebMD LLC. Most people with factor V Leiden never develop abnormal clots. Fiber (whole-grain cereal, beans, wild rice, flourless wheat bread. Maybe youve already had to deal with a blood clot and wonder if youll face another. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Do I need to take medication to prevent additional blood clots? If you cant walk around, flex your ankles and point your toes up and down. Most people who inherit it never develop abnormal blood clots, and may never even know they have the disorder. 0000002967 00000 n Most people with factor V Leiden never develop abnormal clots. The following supplements are theoretically capable of inhibiting VKAs, but their clinical effect is insignificant: Studies have shown that there is a 58% higher likelihood of achieving PT-INR values in the optimal therapeutic range of 2.0 to 3.0 if patients on VKA medication avoid herbal supplements or take them three or fewer times a week. Direct oral anticoagulants (DOACs) are expected to replace VKAs because of their increased safety margin. https://www.uptodate.com/contents/search. Depending on the severity of symptoms, other treatments may be necessary as well. In a healthy individual who is bleeding, platelets and clotting factors or specific proteins form a clot to stop the bleeding. Inherited thrombophilias in pregnancy. Mayo Clinic does not endorse companies or products. When the bleeding stops, different proteins tell the clotting factors to break apart so the clot can dissipate. On the other hand, chronic alcohol consumption reduces the INR. There is also a 50% chance that your child will inherit your normal Factor V gene. US Pharm. What are my treatment options if a mutation is found? The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. Researchers have found that the factor V Leiden mutation involves one small change in the proteins structure. U.S. National Institutes of Health, National Human Genome Research Institute. The mutation does not cause any symptoms in and of itself. 8( x@YB.X0v@+::0Xv|@Q-s4>p03(/` `F0.oCD8}.n)2`b#jPv!A CPt k*6@)V+`b@@\crT0. It is generally advised that patients taking anticoagulants keep to a balanced and consistent diet balanced throughout their treatment course to avoid fluctuations in treatment efficacy. This is known as deep vein thrombosis (DVT), which most commonly occurs in the legs. Some people only need treatment for three months, but others will need blood thinner treatment indefinitely. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. The disorder is most common in people who are white and of European descent. That risk is several times higher in homozygous carriers. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). How long do I need to take the anticoagulant? Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). This site complies with the HONcode standard for trustworthy health information: verify here. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). But not everyone with the prothrombin gene mutation and a history of deep vein thrombosis or pulmonary embolism needs blood thinners during pregnancy. You won't go hungry on The 5-Factor Diet. In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge. If you have never had a blood clot, you do not need treatment with blood thinners. These conditions can be life-threatening and require immediate medical treatment. Leg wraps that inflate and deflate to keep blood moving in your legs. You must do the 25-minute 5-Factor workout five days a week. 6. Should people with Factor V Leiden avoid Vitamin K? you have a medical emergency, call 911 immediately. Some clots do no damage and disappear on their own. The Best Foods to Eat for Promoting Healthy Cells, Your 4-Week Mediterranean Diet Meal Plan, Curated by a Dietitian-Chef, Ready to Try the DASH Diet? This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. 3. Anticoagulant Food-Drug Interactions. Deep vein thrombosis and pulmonary embolism. Deep vein thrombosis and pulmonary embolism. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. Accessed June 4, 2018. The sooner you receive care, the better your chances of a good outcome. Self-care therapies to support your reproductive health; Foods to limit when you're following a heart-healthy diet include: 1. 3. People with Factor V Leiden make an altered factor V protein as a result of a mutated gene. Research is mixed concerning the weight loss advantage of eating smaller meals more often, but this may have other health benefits. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). Alcohol interacts with a large number of medications. Check with your provider. Laboratory testing (blood tests) diagnose this disorder. Following your providers guidance can help you catch and resolve problems early before they interrupt the flow of your life. Mayo Clinic is a not-for-profit organization. Talk to your healthcare provider to receive advice tailored to your needs. 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Do I need to limit my activity in any way? Accessed June 4, 2018. The prevalence of factor V Leiden varies by ethnicity. 0000239923 00000 n Middeldorp S, Coppens M. Hereditary Thrombophilia. Mango and St. Johns wort are also clinically relevant inhibitors of VKAs. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Where's the Health Benefit? News-Medical. But you should talk to your provider about what you can expect in your individual situation. As such, daily intake or extra supplementation with vitamin K is typically unnecessary to keep body stores at healthy levels. If you have symptoms of a pulmonary embolism, you should go to the closest emergency room. Rather, it's key to keep your intake of the nutrient consistent. A DVT may not cause any symptoms. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. Having additional genetic blood clotting disorders. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Zoppi, Lois. There are no pre-made foods or supplements to buy. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. If you have the disorder, you may never develop a blood clot. Accessed June 4, 2018. The factor V Leiden mutation itself doesnt cause any symptoms. The factor V Leiden mutation does not itself cause any symptoms. This field is for validation purposes and should be left unchanged. When you need health care or go to the hospital, tell your healthcare team that you have Factor V Leiden, so that they can plan the care you need. Does my factor V Leiden need to be treated? We do not endorse non-Cleveland Clinic products or services. These include deep vein thrombosis, factor V Leiden, myocardial infarction, and polycythemia vera, among many others. "Anticoagulant Food-Drug Interactions". Factor V Leiden may lead to deep vein thrombosis or a pulmonary embolism, which are serious medical emergencies. I was diagnosed in 2001 after a series of TIA's and a smart neurologist who suspected there was something more to be investigated since I had a history of DVT's and my mother's family has had numerous blood clots. Counseling prior to taking birth control pills or before becoming pregnant. A family history of factor V Leiden increases your risk of inheriting the disorder. Factor V is a protein or clotting factor that helps create the enzyme reactions that form the fibrin in the clot. When enough fibrin has been made, a substance called activated protein C (APC) inactivates factor V, helping stop the clot from growing any larger than necessary. If youve had a deep vein thrombosis or pulmonary embolism before and know you have the prothrombin gene mutation, you may need a prescription for low-dose (preventive doses) of an injectable blood thinner (such as heparin or a low-molecular-weight heparin) during your pregnancy and for a few weeks after delivery. Lockwood CJ, et al. It may ease your mind to know that most people with this disorder never have a blood clot. Accessed June 4, 2018. You may be treated with blood thinners until the risk has passed. A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. All rights reserved. 78 0 obj<>stream If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Avoid playing contact sports or engaging in other activities that could result in physical injury. The Top 5 Worst Foods for Your Heart, According to a Dietitian. Blood clots in less commonly affected veins, like those in your liver or brain. 2. Zoppi, Lois. If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. On a long flight, take regular walks down the aisles of the plane. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . What can I do to support a healthy pregnancy? Lockwood CJ, et al. Get useful, helpful and relevant health + wellness information. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. 4. People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Larger than normal veins near your skins surface. Low-salt, low-fat: The plan is already geared toward low-fat and low-salt foods and may be adjusted further if needed. The factor V Leiden mutation changes this proteins structure. Cleveland Clinic is a non-profit academic medical center. Current management strategies involve the use of pharmacotherapy, when indicated, in the event of deep venous thrombosis or pulmonary embolism. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. NBCA provides the information and materials on this site for general information purposes only. Vitamin K antagonists (VKAs) are the most commonly prescribed oral anticoagulants worldwide. I WAS DIAGNOSED IN MARCH OF THIS YEAR AFTER HAVING MY 2ND PULMONARY EMBOLISM. Factor V Leiden is the most common one. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. 0000237253 00000 n It is not associated with an increase risk of cancer or birth defects. Most people with factor V Leiden never develop abnormal clots. More info. Factor V is a protein that is needed for blood to clot properly. Having Factor V Leiden does not appear to increase the chances of developing a heart attack or stroke. Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. Hereditary thrombophilia. Dont buy ones from the store or wear them without talking to your provider first. 0000000016 00000 n In 2010 I was pregnant with my son. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. Philadelphia, PA 19182-5687. They were hot, red, and huge. 0000237061 00000 n It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. The clotting action of Factor V is controlled by another protein called Activated Protein C. To stop blood from forming clots, Activated Protein C easily turns off Factor V. Activated Protein C does not work as well on the abnormal Factor V Leiden protein. Nelson JG. About 1 of every 250 Black people in America has the prothrombin gene mutation. Please note that medical information found If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. Get useful, helpful and relevant health + wellness information. In rare cases, you may need a catheter procedure or surgery to remove the bulk of the clots. If you notice any of these problems, call your doctor right away. small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. If you smoke, consider the benefits of quitting. You may inherit an abnormal Factor II gene from one or both parents. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. It increases the chances that your blood will form abnormal blood clots that can be dangerous. These blood clots can be life-threatening. 3. If you have this disorder, you may experience: Factor V Leiden doesnt raise your risk of heart attacks, strokes or blood clots in the arteries of your legs. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater. But the plan would have to be modified to make it appropriate if you have these or other conditions. As a result, clotting goes on longer than usual. Enjoy a variety of foods from the 4 food groups. Factor V Leiden thrombophilia. The plan does not address the differences in calorie needs of each individual. Chan School of Public Health. 2. Fatty fish: Aim for two servings of fatty fish each week, such as salmon, tuna and sardines. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). https://www.uptodate.com/contents/search. It even tells you what staples to keep on hand so you will always be able to get a quick meal together. This will help to avoid miscarriage or pregnancy complications for the following reasons: . It is important to discuss potential interactions between existing and new medications to prevent or recognize any side effects. It is not a disease. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. In the spring of 2010, I was working and felt that it was a little difficult to bend my right knee / walk - I felt very little swelling / heat so I thought little of it, especially in light of a prior history of having knee problems in that same leg. Information on diseasemaps.org is reported by users and is not medical advice. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. Venous thromboembolism. The 5-Factor Diet is a bundled diet and exercise plan that may help you lose weight and become more active. In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed. Vitamin K is a necessary element in the blood clotting process. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). The amount of weight that you can lose, however, depends on many things, including your size, gender, and activity level. Vegetarians and vegans: You can easily modify the 5-Factor Diet for vegetarian and vegan diets, though the protein sources for vegans are somewhat limited. %PDF-1.5 % Here's some information to help you prepare for your appointment. Will Eating More Protein Help Your Body Gain Muscle Faster? Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. In your body, you have 50% Factor V Leiden and 50% normal Factor V. This happens in about 5 out of 100 people of Caucasian decent. Phone: 703.935.8845 The two most common hereditary thrombophilia conditions are the factor V Leiden and prothrombin 20210 gene mutations, both of which have been the subject of previous Cardiology Patient Pages. Carbohydrates with lower glycemic index (GI) values raise blood sugar levels less than foods with a higher GI, but their use in weight loss has not been as well studied. This helps keep the blood flowing in your legs. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. Your skin may also feel warm to the touch or look red or discolored. Foods to eat: Foods high in salicylates such as ginger, prunes, cranberries, oranges-prevent formation of blood clots Foods to avoid: Vitamin K rich Foods such as kale, collard and. This change causes it to resist other proteins that stop excessive clotting. A lot of people carry the genetic mutation and a few people develop blood clots that are related to Factor V Leiden. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Some research suggests that women with the Factor V Leiden gene who have had pregnancy losses may have a greater risk of miscarriages. Anticoagulant Food-Drug Interactions. Factor V Leiden causes hypercoagulability, which makes it harder for your blood clots to break up. Can the results of the test affect my ability to obtain health insurance? Factor V that becomes impaired can cause numerous issues with the health of the human blood. Women have a greater chance of developing a blood clot during pregnancy. Vitamin K is found in the following foods: Flaxseed may inhibit the proper absorption of anticoagulants. At this time, we cant treat or change our genes. They are used to treat conditions such as embolic ischemic stroke, deep vein thrombosis, and pulmonary embolism. What are my risks? The majority of people born with this mutation will not develop an abnormal blood clot in their lifetime. You may be treated with blood thinners during this time. Healthy fat (from fish such as salmon, tuna, mackerel, sardines, rainbow trout, or peanut oil, olive oil, canola oil, sunflower oil, Sugar-free drinks (water, sugar-free soda, coffee, tea, or an unsweetened energy drink). But if you do, prompt treatment can manage your condition. You inherit this condition from one of your biological parents. All rights reserved. In this interview, we speak to Ceri Wiggins, a Director at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies. This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. Even if you develop a blood clot, prompt treatment can prevent a fatal outcome. Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Both men and women can have factor V Leiden. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. (https://pubmed.ncbi.nlm.nih.gov/34540419/), (https://www.genome.gov/Genetic-Disorders/Factor-V-Leiden-Thrombophilia), (https://medlineplus.gov/lab-tests/coagulation-factor-tests/), (https://medlineplus.gov/genetics/gene/f5/), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). You will most likely not have a dangerous blood clot, but your provider can provide counseling on how to reduce the risk of a deep vein thrombosis or pulmonary embolism. Some hospitals do only the DNA test and not the screening test. Pasternak promises that eating a balanced meal five times a day will keep your blood sugar low and stable. DVT or a PE during or shortly following pregnancy. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. Barbara Woodward Lips Patient Education Center. Heterozygous Factor V Leiden If you inherited one Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. The condition it self does not require a special diet. A. Green tea in high amounts could reduce PT-INR values. At least 1 of the genes that you inherited is the mutated gene that makes the Factor V Leiden protein. Factor V and other proteins work together to help your blood clot when necessary. Calorie counting is not a feature of this diet plan. 0000000856 00000 n Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene.