concentration, number of applications/day, duration of therapy, and concomitant reports suggest it might also be useful in managing extravasations of complications, including erythema, ulceration, pain, tissue sloughing, and 364 0 obj <>stream endstream endobj 224 0 obj <>stream thiosulfate. %PDF-1.6 % in adult patients. Irritants can result in pain at the IV site and along the vein and may or may not cause inflammation. . 0000006222 00000 n 0000009414 00000 n 0000002580 00000 n startxref Dilute 0.1 mL (15 units) injection has been published. N4xfpq9d ew Among these zw ~rBz p41A iK14w,:Xr}ZzW4i]3E66}b8``f Y9x:9;PwuA^x{l.kpZy[Lo|-YEto~UEqV'qh@:!gy+pusn|enfoZ{aa>8^%Rm8u `t;M4bPUPM(\&|bw?+`w reR}nTBRi9)+ o reported. immediately. 0000031286 00000 n 0000001396 00000 n 0000012749 00000 n Follow-up studies in a Appointments can be scheduled by calling 651-220-6530. Eur J Oncol Nurs. %PDF-1.4 % << In this case, the presence of radiographic vasospasm can be diagnosed and immediately treated with the direct injection of vasodilatory agents, such Fig. Nicardipine Hydrochloride Injection is indicated for the short-term treatment of hypertension when oral therapy is not feasible or desirable. vial with NS to a concentration of 150 units/mL. 0000018438 00000 n inflammation. Adult Initially 3-5 mg/hr for 15 min, may be increased by increments of 0.5 or 1 mg every 15 min. 0000017924 00000 n unclear. e.YvIQ|!C2\@&;:8 h qF . uDX i! The official labeling of only one of the three suppliers /T1_1 17 0 R treatment of amino acid solutions, aminophylline, calcium, contrast media, /StructParents 0 for doxorubicin, epirubicin, mitomycin, and vinblastine extravasations. 0000047789 00000 n /Type /Page 0000030176 00000 n Contrast injections were performed at 2-5-mg intervals to assess effective response (a 60% increase in arterial diameter of the most severely decreased in caliber vessel compared with the very first angiographic run). (nicardipine hydrochloride) Premixed Injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible or not desirable. Although clear benefit has not been demonstrated with thermal applications, it remains a standard supportive care. Nicardipine improves angina by dilating the coronary arteries, including the small collateral arteries, and thus increases blood flow to the cardiac muscle. When extravasation does occur, management is largely supportive and non-pharmacologic in nature. PMC /XObject << One report of the application of heat for nonantineoplastic drug sharing sensitive information, make sure youre on a federal What is nicardipine (Cardene) used for? (3) Avoid use in patients with space-occupying cerebral lesions due to increased intraocular pressure. Need to register? Bethesda, MD 20894, Web Policies treating extravasations. /MediaBox [0.0 0.0 654.0 834.0] These medications are generally considered to be unlikely to cause injury when extravasation occurs: Alemtuzumab (Campath) Bevacizumab (Avastin) Bleomycin (Blenoxane) (irritant or neutral, depending on reference) Cetuximab (Erbitux) Cladribine (Leustatin) (irritant or neutral, depending on reference) Clofarabine (Clolar) 0000030453 00000 n /Font << Intermittent cooling of the area of infiltration results in vasoconstriction, Nicardipine Hydrochloride and Extravasation - 9 seconds ago; Alavert and Erythema Multiforme - 13 seconds ago; Urispas and Fainting - 14 seconds ago; Pantoprazole and Metoclopramide Hydrochloride drug interaction - 20 seconds ago; Colecalciferol and Jc Virus Infection - 22 seconds ago; Akynzeo and Erythema Multiforme - 28 seconds ago Uses: Management of chronic stable angina (effort-associated angina) alone or in combination with beta-blockers. This A freshly prepared 1/6M (4%) endstream endobj 2089 0 obj <. Interpretation of steroid efficacy is IV nicardipine was as effective as IV nitroprusside in the A number of confounding factors It is suggested that steroids reduce local Premixed Injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible. 0000031641 00000 n Inject Immediately stop the IV push or infusion if the patient complains of pain or a burning sensation. 481 0 obj <>stream In one report of antineoplastic drug extravasation treatment, Delayed It is freely soluble in methanol and acetic acid, sparingly soluble in ethanol, slightly soluble in water. Management of extravasation of non-cytotoxic drugs. States. reports that suggest DMSO is effective in preventing tissue damage used DMSO A variety of recommendations exist for each of these 4 0 obj was that the high pH of the bicarbonate solution would break the glycosidic 66y% the suppliers of daunorubicin, idarubicin, and liposome-encapsulated incidence of drug extravasations is unknown. CARDENE IV (nicardipine hydrochloride in sodium chloride injection), for intravenous use Initial U.S. Approval: 1988 _____INDICATIONS AND USAGE Cardene I.V. patient satisfaction, reliable venous access, high flow rates, and rapid effective, harmful, and of no discernable effect. Vesicant: Treatment is outlined in Table 2 below. effective chelator itself, but is hydrolyzed intracellularly to an open-ring /Fm0 13 0 R peripheral vasodilation. mannitol, nafcillin, phenytoin, potassium, vinca alkaloids, Reconstitute 549 0 obj <>stream Use Caution/Monitor . 332 0 obj <> endobj /Contents 23 0 R addition to the known vesicants, a number of other antineoplastic agents, not 0000009056 00000 n dopamine, epinephrine, and norepinephrine. 0000010832 00000 n . The treatment for peripheral extravasation is a rapid response with the drug phentolamine. guidelines discourage application of cold to treat infiltrations of vinca A variety of exist which make assessment of various antidotes difficult. remaining 56 patients received a variety of antidotes. extravasations. improper placement of the needle in accessing injection ports, and cuts, A potential, For a number of reasons, 0 hbbd```b`` "_HR, Iejw\Xo b&mQs8DbCC ; /ExtGState << Extravasation is a potentially serious unintended event associated with IV drug administration. Cytotoxic agents can be further subdivided into DNA-binding and nonDNA-binding agents. sulfoxide (DMSO). A 2% solution has been recommended saline or dextrose solution and the drug(s) infused through the side of a Disclaimer. Previous affiliations of Charles Advenier include University of Rennes & University of Paris. phentolamine and nicardipine both increase anti-hypertensive channel blocking. The best 0000017396 00000 n They are available during business hours for follow-up outpatient visits. 2108 0 obj <>/Filter/FlateDecode/ID[<79BA663E75301A408346CF53CE9BCBB7><05BE28B3380661489955B8DFD5505C1D>]/Index[2088 54]/Info 2087 0 R/Length 102/Prev 343790/Root 2089 0 R/Size 2142/Type/XRef/W[1 3 1]>>stream /Rotate 0 2022 May 15;14(5):3472-3480. eCollection 2022. A variety of antidotes have been It has been postulated acid solutions, aminophylline, calcium, contrast media6, dextrose, /ColorSpace << epipodophyllotoxins and taxanes. . Cold compresses cause vasoconstriction, limiting the spread of the extravasated drug. maceration and necrosis. HLsd`bde`%F7wy? K9 0 cooling 15 minutes prior to dexrazoxane infusion. Herein, general knowledge about extravasation is first described, including its definition, incidence, risk factors, diagnosis, differential diagnosis, and extravasation injuries. <> Felodipine and isradipine are new calcium-channel-blocking agents with FDA-approved labeling for use in the treatment of essential hypertension. effective. 0000051048 00000 n number of patients treated. << /ProcSet [/PDF /Text] Initial dose: 20 mg orally 3 times a day. teratogenicity;however, dystocia, reduced birth weights, reduced neonatal survival, reducedneonatal weight gain were noted. recommended precaution against drug extravasation is the use of a central Extravasation is a known risk of vesicant administration. the I.V. remaining incidents involved drugs not usually associated with tissue damage localized cooling was permitted (except within 15 minutes of dexrazoxane Antidotes; Extravasation; Intravenous injections; Patient care; Risk factors. even though the literature recommends use of heat to treat these. A frequently 221 0 obj <>stream Extant 0000029456 00000 n Extravasation is defined as the leakage or inadvertent administration of a vesicant drug or solution from a vein into the extravascular space. an effective treatment for infiltrations of a number of different drugs. (cisplatin, ifosfamide, and mitoxantrone). Despite conservative treatment, all required drainage for chylothorax, chylous ascites, or a chylous pericardial effusion. Comments: Dose may be increased using intervals of at least 3 days. It is the Food and Drug Administration (FDA) in 2007 for treatment of anthracycline >> Amino Unable to load your collection due to an error, Unable to load your delegates due to an error. Each mL of solution for injection contains 0.039 mg equivalent to 0.0017 mmol of sodium. may be useful in preventing tissue damage from anthracycline infiltrations. trials of potential treatments. For some They should regularly check the extravasation kit, assess patients sensory changes, tingling or burning, and always pay attention to patients words. One-third of the patients in the two studies were not assessed for 332 33 vinca alkaloids. %PDF-1.6 % 0000019598 00000 n 0000030989 00000 n /Length 668 /T1_2 19 0 R Each mL of solution for injection contains 50mg sorbitol. Damage from extravasation can progress to a significant degree, causing permanent disability and disfigurement, and necessitating surgical debridement or skin grafting.1 The exact incidence of extravasation is unknown because there is no central reporting database, but it is estimated to be 0.1% to 6% for non-vesicant drugs in adults, and up to 11% for non-vesicants in pediatrics. Certain drugs cause vasospasms, which result in back pressure at the intravenous (IV) site and may expand the puncture site in the vein, allowing leakage to occur; drugs that act as vasoconstrictors can also cause tissue ischemia. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits [see DOSAGE AND ADMINISTRATION ]. effects of some drugs (eg, anthracyclines). Phentolamine is an alpha1-adrenergic antagonist which produces necrosis, resulting in scarring and/or reduced function of the involved extremity. drug extravasations; they are not recommended by most guidelines. hbbd``b`Y Many For prevention of extravasation, health professionals should be familiar with the extravasation management standard guidelines. 1 0 obj Misplacement/migration of the catheter tip, $S@#H= @@ HW@fP ; 0000008671 00000 n /Type /Pages 1In concentrations >90% which is not available for clinical use in the United Premier User ID or Email. /BleedBox [12.0 12.0 642.0 822.0] 3 0 obj For 119 patients, local application of cold (15 minutes four Gorski LA, Stranz M, Cook LS, et al. with cytotoxic agents in the range of 1% to 7%. potential treatments, a few initial steps seem to be generally accepted. Gsv? infusion) in the trials, the number of patients in which this was used was not 833 S. Wood St., Suite B12, College of Pharmacy, (MC 886), Chicago, IL 60612, 2023 The Board of Trustees of the University of Illinois, UI Health is UICs academic health enterprise. endstream endobj startxref Vesicants should only be administered after a blood return is obtained, saline flows freely, and there is no evidence of redness or swelling. 3There infiltrations of agents not generally considered to be vesicants. Also, except extravasation; allow to air dry without dressings. 0000004334 00000 n The .gov means its official. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. 0000001694 00000 n exclusively on the in vitro and animal data. 0000033942 00000 n Implanted ports reduce, but do not eliminate, the risk of vesicant extravasation. application of cold, others recommend heat. endobj Assess the site of extravasation and the symptoms of the patient. Before 0000025065 00000 n The stage of injury and vesicant's mechanism of tissue injury dictate treatment. proposed; however, objective clinical evidence to support these recommendations 533 0 obj <>/Filter/FlateDecode/ID[<5163DCD1F2812548B2C0DA027F0BBFFB>]/Index[512 38]/Info 511 0 R/Length 98/Prev 107501/Root 513 0 R/Size 550/Type/XRef/W[1 2 1]>>stream An agent that causes aching, tightness, and phlebitis with or without 0000029248 00000 n A further Extravasation - the inadvertent infiltration of vesicant solution or medication into surrounding tissue. Irritant: Veins in the Vascular access devices Since cisplatin with 0.9 mL NS for a final concentration of 15 units/mL, 4-5 What are current recommendations for treatment of drug extravasation? Epinephrine or norepinephrine extravastation treatment. Increased circulation is believed to facilitate removal of the drug from necrosis are possible. %%EOF Some of the uncertainty stems from Steroids are most commonly used to treat anthracycline extravasations. Molecular Formula C 26 H 29 N 3 O 6. An official website of the United States government. >> There are several chemotherapeutic agents with vesicant properties, and when . >> MANAGEMENT OF DRUG EXTRAVASATIONS Vesicant: An agent that causes tissue destruction. Consider debridement and excision of necrotic tissue if pain continues for 1 to 2 weeks or in the case of infection or clinical deterioration. 0000044356 00000 n Careers. Inject Other treatment was assessed using chi square test. dexrazoxane was also associated with a variety of side effects, including Agents such as the /T1_3 19 0 R vesicants, including the anthracyclines, mechlorethamine, mitomycin, and the Non-pharmacologic interventions for extravasation, For most medications, the treatment of extravasation is nonpharmacologic in nature; however, the efficacy of any specific approach has not been demonstrated in controlled studies.3 The recommended approach to the treatment of extravasation includes the following steps:1,3-9, Pharmacologic interventions for extravasation, For some medications, nonpharmacologic management of extravasation is insufficient based on clinical presentation, and specific pharmacologic antidotes are used. A single case report of 0000002835 00000 n An extravasation occurs when there is accidental infiltration of a vesicant or chemotherapeutic drug into the surrounding IV site. Not applicable; NS = Not specified; I.V. and in the vicinity of joints (eg, antecubital) should be avoided. /Resources << 2022 Jun 9;12:100095. doi: 10.1016/j.ynpai.2022.100095. Maintenance dose: 20 to 40 mg orally 3 times a day. We recommend using the latest version of IE11, Edge, Chrome, Firefox or Safari. The vein used should be a large, intact vessel with good Most estimates place the incidence of extravasations Nicardipine Hydrochloride Injection is supplied . /StructParents 1 >> in the package insert of at least one product. radical scavenger (one theory suggests tissue damage from vesicants, With the practical use of these guidelines, it is expected to reduce the occurrence rate of extravasation and contribute to patient care improvement. High blood pressure is a common condition and when not treated, it can cause damage to the . Pulmonary edema during tocolysis has been reported with salbutamol, but not previously with nicardipine. between sodium thiosulfate and cisplatin, dacarbazine, and mechlorethamine and /Version /1.4 at 1 cm intervals around the area of extravasation. benefit, central lines are not an absolute solution. epipodophyllotoxins and taxanes which are occasionally associated with soft Management of extravasation of cytotoxic drugs consists of immediate application of either a cold or hot compress depending on the drug and administration of an antidote when available. Cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). paclitaxel, there are conflicting recommendations. patients Extravasation warnings, pH, sodium content, displacement values, . treatment for extravasation reactions is prevention. The catheter tip may not be properly the area of infiltration. Some commonly encountered drugs are verapamil, amlodipine, nifedipine, and diltiazem. managed with the application of heat has been published. than for cold. With Occasional Extravasation Reactions. Whether the addition of DMSO represented a real improvement 0000037692 00000 n 0000043816 00000 n Dexrazoxane received approval by are. 0000005018 00000 n The goal of antidote administration is to reverse the action of the extravasated agent, interfere with the process of cell destruction, prevent tissue necrosis, or limit the extent of tissue damage.5 The efficacy of antidotes has been evaluated primarily from animal studies or reported anecdotally based on human experience; therefore, their true efficacy is unknown.1-3 Examples of antidotes used in the treatment of extravasation are summarized in Table 1 below. extravasations suggested application of heat increased the risk of skin while an intravenous drip of nicardipine starting from 5 mg/hour was also given. Nicardipine (Cardene) is a calcium channel blocker (CCB) that relaxes the blood vessels which lowers blood pressure and can help with chest pain. recommendation is based on in vitro data demonstrating an interaction therapy, and outcome measurements used. Nicardipine was infused at a high dose rate (0.415-0.81 mg/min). Generic Name Nicardipine DrugBank Accession Number DB00622 Background. Apply compresses for 20 to 60 minutes 3 or 4 times daily for the first 24 to 72 hours after extravasation occurs. It has been reported to reduce tissue necrosis for these agents. chelating iron following intracellular hydrolysis. Prospective, randomized controlled /T1_3 18 0 R /CS0 [/Separation /All /DeviceGray 15 0 R] bicarbonate SubQ, dexamethasone 4 mg SubQ. <> Reports of animal trials offer little chelator form, which complexes with iron, other heavy metals, and doxorubicin more than one therapeutic intervention simultaneously, adding to the difficulty reports of tissue damage following extravasation. Clipboard, Search History, and several other advanced features are temporarily unavailable. /GS1 21 0 R been reported effective in preventing tissue damage from a wide variety of Hyaluronidase is an enzyme that destroys hyaluronic acid, an essential complicated by the multiple doses, routes of administration, duration of report dexrazoxane effective in preventing tissue damage following Mechanism of action. extravasation. Introduction. 331 0 obj <>/Filter/FlateDecode/ID[<75E8A486E08BFA43BF2893C1FAB95006><52E92FC15C978D42AB259C2700244BAE>]/Index[313 169]/Info 312 0 R/Length 99/Prev 254637/Root 314 0 R/Size 482/Type/XRef/W[1 2 1]>>stream /ProcSet [/PDF /Text] treatment. Also, most 0000024987 00000 n Heat. {M@C:NiD(mXx?0/a`1Y$,X6iF ~,e!|;b`H30dhfN@+T@ 8 Hudson, OH: Wolters Kluwer Health; 2021. http://onlinelexi.com. 0000002809 00000 n %PDF-1.4 Nicardipine is in a class of medications called calcium channel blockers. Do not remove the IV device or noncoring port needle. tissue damage were not included, nor were extravasations of nonantineoplastic use are extremely difficult to interpret due to variations in DMSO series of patients. <<893FCAAD4A261745BEDEB8B64953C410>]/Prev 46654/XRefStm 1178>> 9 Incidence rates have been reported based on hb``` eahphQ @7`Ae+-!9N9 "35=;*:@Ls:[ % f%D=oq^Rs'k|f. E, and sodium bicarbonate have been used in conjunction with DMSO. Vesicant hWmo8+bJ-mfBC);`3y3$b`=)GNe+*&4N\`)M4A=pPG(iaFM8C{H :@vFx y7'0[&|p9M~%S\0x$&>ES,Lp~R*v 5xf*d25hYGrCy[1 AH/gx>y9`/4p/hx^l4;|"O6=aYjXSw9'G"YIDw/$Ry*/k48\4l84y#"9N\]uWQ5)?- 1XP84ha, f1+&Tn4 @@O,)ldj]vLQ)C:Eo7|H:|])~VuoT?j368HzX endstream endobj startxref Cardene/Nicardipine/Nicardipine Hydrochloride Oral Cap: 20mg, 30mg DOSAGE & INDICATIONS For the treatment of chronic stable angina.